54 research outputs found
Relations in biomedical ontologies
To enhance the treatment of relations in biomedical ontologies we advance a methodology for providing consistent and unambiguous formal definitions of the relational expressions used in such ontologies in a way designed to assist developers and users in avoiding errors in coding and annotation. The resulting Relation Ontology can promote interoperability of ontologies and support new types of automated reasoning about the spatial and temporal dimensions of biological and medical phenomena
The SOFG Anatomy Entry List (SAEL):an annotation tool for functional genomics data
A great deal of data in functional genomics studies needs to be annotated with
low-resolution anatomical terms. For example, gene expression assays based on
manually dissected samples (microarray, SAGE, etc.) need high-level anatomical
terms to describe sample origin. First-pass annotation in high-throughput assays (e.g.
large-scale in situ gene expression screens or phenotype screens) and bibliographic
applications, such as selection of keywords, would also benefit from a minimum
set of standard anatomical terms. Although only simple terms are required, the
researcher faces serious practical problems of inconsistency and confusion, given
the different aims and the range of complexity of existing anatomy ontologies. A
Standards and Ontologies for Functional Genomics (SOFG) group therefore initiated
discussions between several of the major anatomical ontologies for higher vertebrates.
As we report here, one result of these discussions is a simple, accessible, controlled
vocabulary of gross anatomical terms, the SOFG Anatomy Entry List (SAEL).
The SAEL is available from http://www.sofg.org and is intended as a resource
for biologists, curators, bioinformaticians and developers of software supporting
functional genomics. It can be used directly for annotation in the contexts described
above. Importantly, each term is linked to the corresponding term in each of the
major anatomy ontologies. Where the simple list does not provide enough detail or
sophistication, therefore, the researcher can use the SAEL to choose the appropriate
ontology and move directly to the relevant term as an entry point. The SAEL links will
also be used to support computational access to the respective ontologies
Claudins in renal physiology and disease
The tight junction forms the paracellular permeability barrier in all epithelia, including the renal tubule. Claudins are a family of tight junction membrane proteins with four transmembrane domains that form the paracellular pore and barrier. Their first extracellular domain appears to be important for determining selectivity. A number of claudin isoforms have been found to be important in renal tubule function, both in adults and in neonates. Familial hypomagnesemic hypercalciuria with nephrocalcinosis is an autosomal recessive syndrome characterized by impaired reabsorption of Mg and Ca in the thick ascending limb of Henle's loop. Mutations in claudin-16 and 19 can both cause this syndrome, but the pathophysiological mechanism remains controversial
Impact of Optimized Breastfeeding on the Costs of Necrotizing Enterocolitis in Extremely Low Birthweight Infants
To estimate risk of NEC for ELBW infants as a function of preterm formula and maternal milk (MM) intake and calculate the impact of suboptimal feeding on NEC incidence and costs
Proceedings of the Thirteenth International Society of Sports Nutrition (ISSN) Conference and Expo
Meeting Abstracts: Proceedings of the Thirteenth International Society of Sports Nutrition (ISSN) Conference and Expo Clearwater Beach, FL, USA. 9-11 June 201
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